Sayre is the largest borough in Bradford County, Pennsylvania, 59 miles (95 km) northwest of Scranton. In the past, various iron products were made there. In 1900, 5,243 people lived there; in 1910, 6,426 people lived there, and in 1940, 7,569 persons made their homes in Sayre. The population was 5,587 at the 2010 census. Children residing in the borough are assigned to attend the Sayre Area School District.
Sayre is home to the Robert Packer Hospital and Guthrie Clinic. Sayre is also in a small area called 'The Valley,' a group of four contiguous communities in New York and Pennsylvania: Waverly, New York; South Waverly, PA; Sayre; Athens, PA, and smaller surrounding communities with a combined population near 35,000 of the Greater Valley.
Sayre borders, and is contiguous with, Waverly, New York; South Waverly, Pennsylvania; and Athens, Pennsylvania..